HitPredict

Interactor 1: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Interactor 2: BBX (Q8WY36)
HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)
Gene: BBX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 486 Hs			1 941
+	Hs
		817813 MECP2_HUMAN (1-486): 5.16e-113: 344: 100.00		SOX2_HUMAN (39-325): 5.4e-55: 195: 17.47
+	Hs
		727954 MECP2_HUMAN (1-486): 5.16e-113: 344: 100.00		SOX18_HUMAN (59-306): 1.06e-35: 141: 16.93
+	Mm
		1142026 MBD3_MOUSE (93-249): 2.35e-44: 159: 26.25		Q60I23_MOUSE (39-325): 1.71e-56: 199: 17.47
+	Hs
		328506 MBD3_HUMAN (93-249): 3.06e-43: 156: 26.88		SOX2_HUMAN (39-325): 5.4e-55: 195: 17.47
+	Hs
		818556 MBD2_HUMAN (75-249): 3.32e-38: 146: 28.65		SOX2_HUMAN (39-325): 5.4e-55: 195: 17.47
+	Hs
		328641 MBD3_HUMAN (93-249): 3.06e-43: 156: 26.88		CIC_HUMAN (48-324): 1.44e-38: 158: 24.83
+	Hs
		727818 MBD2_HUMAN (75-249): 3.32e-38: 146: 28.65		SOX5_HUMAN (41-244): 7.5e-36: 148: 18.10
+	Hs
		727936 MBD2_HUMAN (75-249): 3.32e-38: 146: 28.65		SOX6_HUMAN (68-282): 2.73e-35: 146: 15.98
+	Hs
		1300983 MBD1_HUMAN (95-220): 6.98e-31: 127: 31.78		CIC_HUMAN (48-324): 1.44e-38: 158: 24.83
+	Hs
		818155 NIPBL_HUMAN (72-455): 1.96e-09: 62.4: 14.06		SOX2_HUMAN (39-325): 5.4e-55: 195: 17.47