HitPredict

Interactor 1: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	12670868, 15199122, 20126307
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 2035 Hs			1 1273
+	Ce
		60808 HCF1_CAEEL (1648-2035): 7.28e-41: 166: 32.77		SIN3_CAEEL (60-1079): 0: 716: 19.90
+	Hs
		257758 HCFC1_HUMAN (1-2035): 0: 643: 100.00		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Dm
		1137167 HCF_DROME (948-2031): 9.87e-34: 144: 15.87		Q5U0Y0_DROME (35-539): 2.36e-50: 198: 21.88