HitPredict

Interactor 1: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Interactor 2: CXXC1 (Q9P0U4)
CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
Gene: CXXC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	23870121, 26496610, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0035097 - histone methyltransferase complex GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... GO:0048188 - Set1C/COMPASS complex
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 2035 Hs			1 656
+	Hs
		62457 A6NEM2_HUMAN (1-2035): 0: 626: 97.79		CXXC1_HUMAN (1-656): 0: 739: 100.00
+	Hs
		1349850 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		CXXC1_HUMAN (1-656): 0: 739: 100.00
+	Hs
		848317 HCFC1_HUMAN (1-2035): 0: 643: 100.00		KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96
+	Hs
		848199 HCFC1_HUMAN (1-2035): 0: 643: 100.00		KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79
+	Hs
		848318 HCFC1_HUMAN (1-2035): 0: 643: 100.00		PHF8_HUMAN (10-152): 2.11e-29: 127: 23.38
+	Hs
		848281 HCFC1_HUMAN (1-2035): 0: 643: 100.00		DIDO1_HUMAN (3-159): 7.85e-28: 122: 24.85
+	Mm
		876679 HCFC1_MOUSE (1-2035): 0: 609: 92.28		KMT2A_MOUSE (74-359): 3.93e-29: 126: 18.63
+	Hs
		1235438 LZTR1_HUMAN (17-461): 2.92e-79: 283: 16.67		KDM2B_HUMAN (81-356): 1.32e-27: 121: 16.93
+	Hs
		1017293 KEAP1_HUMAN (2-262): 1.96e-59: 219: 17.11		BPTF_HUMAN (17-130): 1.34e-24: 112: 26.09
+	Hs
		1309192 KLDC3_HUMAN (68-425): 9.22e-58: 207: 21.14		DIDO1_HUMAN (3-159): 7.85e-28: 122: 24.85
+	Hs
		1357298 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96
+	Hs
		975356 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79
+	Hs
		1312016 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		DIDO1_HUMAN (3-159): 7.85e-28: 122: 24.85