HitPredict

Interactor 1: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Interactor 2: TIRAP (P58753)
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
Gene: TIRAP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.649

The method score is based on:

Property	Details
Experiments	33961781, 21903422
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002755 - MyD88-dependent toll-like receptor signaling pathway GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007249 - canonical NF-kappaB signal transduction and 6 others more... GO:0009986 - cell surface GO:0032496 - response to lipopolysaccharide GO:0034142 - toll-like receptor 4 signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	712
Hs

1	221

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024