HitPredict

Interactor 1: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Interactor 2: SIGIR (Q6IA17)
Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
Gene: SIGIRR

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	12925853, 15866876
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 712 Hs			1 410
+	Hs
		848489 IRAK1_HUMAN (1-712): 0: 597: 100.00		IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31
+	Hs
		848345 IRAK1_HUMAN (1-712): 0: 597: 100.00		ILRL1_HUMAN (9-320): 1.43e-83: 267: 22.94
+	Mm
		1143080 IRAK1_MOUSE (1-712): 0: 580: 80.93		IL1AP_MOUSE (8-326): 9.25e-89: 281: 22.39
+	Hs
		540387 IRAK1_HUMAN (1-712): 0: 597: 100.00		IL1R1_HUMAN (9-337): 3.46e-82: 264: 20.46
+	Mm
		528286 IRAK1_MOUSE (1-712): 0: 580: 80.93		IL1R1_MOUSE (9-328): 2.26e-80: 259: 19.83
+	Mm
		1142170 IRAK1_MOUSE (1-712): 0: 580: 80.93		IL18R_MOUSE (9-325): 1.24e-72: 238: 25.66
+	Hs
		237482 IRAK1_HUMAN (1-712): 0: 597: 100.00		TLR2_HUMAN (94-307): 3.42e-63: 218: 19.47
+	Hs
		848490 IRAK1_HUMAN (1-712): 0: 597: 100.00		TLR9_HUMAN (107-324): 1.02e-52: 191: 23.21
+	Hs
		237427 IRAK1_HUMAN (1-712): 0: 597: 100.00		TLR5_HUMAN (96-329): 1.09e-50: 184: 16.60
+	Hs
		120140 IRAK1_HUMAN (1-712): 0: 597: 100.00		TLR4_HUMAN (140-316): 1.42e-46: 173: 24.86
+	Mm
		1143893 IRAK1_MOUSE (1-712): 0: 580: 80.93		TLR9_MOUSE (107-318): 7.19e-52: 188: 20.83
+	Mm
		1143895 IRAK1_MOUSE (1-712): 0: 580: 80.93		TLR4_MOUSE (136-315): 3.48e-47: 174: 23.91
+	Hs
		197881 IRAK2_HUMAN (18-687): 1.18e-135: 414: 27.06		IL1R1_HUMAN (9-337): 3.46e-82: 264: 20.46
+	Hs
		848461 IRAK1_HUMAN (1-712): 0: 597: 100.00		MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92
+	Mm
		607559 IRAK1_MOUSE (1-712): 0: 580: 80.93		MYD88_MOUSE (164-307): 6.09e-13: 70.9: 23.45
+	Hs
		179917 IRAK2_HUMAN (18-687): 1.18e-135: 414: 27.06		TLR3_HUMAN (83-313): 2.3e-49: 181: 16.19
+	Hs
		237439 IRAK4_HUMAN (30-524): 4.17e-133: 402: 26.27		TLR5_HUMAN (96-329): 1.09e-50: 184: 16.60
+	Hs
		120179 IRAK4_HUMAN (30-524): 4.17e-133: 402: 26.27		TLR4_HUMAN (140-316): 1.42e-46: 173: 24.86
+	Hs
		197912 IRAK2_HUMAN (18-687): 1.18e-135: 414: 27.06		MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92
+	Mm
		607565 IRAK2_MOUSE (18-687): 6.27e-131: 402: 25.91		MYD88_MOUSE (164-307): 6.09e-13: 70.9: 23.45