HitPredict

Interactor 1: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Interactor 2: IL1AP (Q9NPH3)
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
Gene: IL1RAP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	9371760, 24735611, 9374458, 15044087
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0038172 - interleukin-33-mediated signaling pathway GO:0045087 - innate immune response GO:0070498 - interleukin-1-mediated signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 712 Hs			1 570
+	Mm
		1143080 IRAK1_MOUSE (1-712): 0: 580: 80.93		IL1AP_MOUSE (1-570): 1.31e-120: 369: 89.12
+	Hs
		848345 IRAK1_HUMAN (1-712): 0: 597: 100.00		ILRL1_HUMAN (49-562): 3.94e-86: 279: 24.49
+	Hs
		540387 IRAK1_HUMAN (1-712): 0: 597: 100.00		IL1R1_HUMAN (67-566): 2.25e-77: 256: 22.39
+	Mm
		528286 IRAK1_MOUSE (1-712): 0: 580: 80.93		IL1R1_MOUSE (12-569): 8.3e-82: 268: 22.45
+	Mm
		1142170 IRAK1_MOUSE (1-712): 0: 580: 80.93		IL18R_MOUSE (30-566): 2.01e-75: 250: 25.64
+	Hs
		848400 IRAK1_HUMAN (1-712): 0: 597: 100.00		SIGIR_HUMAN (240-566): 2.09e-61: 210: 24.55
+	Hs
		237482 IRAK1_HUMAN (1-712): 0: 597: 100.00		TLR2_HUMAN (325-546): 1.51e-33: 138: 21.46
+	Hs
		120140 IRAK1_HUMAN (1-712): 0: 597: 100.00		TLR4_HUMAN (405-570): 9.13e-23: 104: 23.39
+	Hs
		965963 IRAK4_HUMAN (30-524): 4.17e-133: 402: 26.27		ILRL1_HUMAN (49-562): 3.94e-86: 279: 24.49
+	Hs
		237427 IRAK1_HUMAN (1-712): 0: 597: 100.00		TLR5_HUMAN (333-529): 1.05e-15: 82.5: 17.23
+	Mm
		1143895 IRAK1_MOUSE (1-712): 0: 580: 80.93		TLR4_MOUSE (405-546): 1.56e-19: 94.9: 23.81
+	Hs
		197881 IRAK2_HUMAN (18-687): 1.18e-135: 414: 27.06		IL1R1_HUMAN (67-566): 2.25e-77: 256: 22.39
+	Mm
		528287 IRAK4_MOUSE (30-523): 1.66e-131: 398: 25.98		IL1R1_MOUSE (12-569): 8.3e-82: 268: 22.45
+	Hs
		540403 IRAK4_HUMAN (30-524): 4.17e-133: 402: 26.27		IL1R1_HUMAN (67-566): 2.25e-77: 256: 22.39
+	Hs
		120179 IRAK4_HUMAN (30-524): 4.17e-133: 402: 26.27		TLR4_HUMAN (405-570): 9.13e-23: 104: 23.39
+	Mm
		1246919 IRAK4_MOUSE (30-523): 1.66e-131: 398: 25.98		TLR4_MOUSE (405-546): 1.56e-19: 94.9: 23.81
+	Hs
		237439 IRAK4_HUMAN (30-524): 4.17e-133: 402: 26.27		TLR5_HUMAN (333-529): 1.05e-15: 82.5: 17.23