HitPredict

Interactor 1: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

The method score is based on:

Property	Details
Experiments	18180283, 23986494, 18347055, 17997719, 21220427, 24735611, 11583588, 23104095
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007249 - canonical NF-kappaB signal transduction and 6 others more... GO:0032991 - protein-containing complex GO:0042803 - protein homodimerization activity GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0046982 - protein heterodimerization activity GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	712
Hs

1	419

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024