HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.898

Property	Details
Experiments	19956605, 32296183, 19549727, unassigned1304
Identification Methods	pull down, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 406
+	Hs
		988038 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		919711 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		1304199 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		849421 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		1318719 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRIM5_HUMAN (39-392): 3.48e-68: 225: 14.85
+	Hs
		849439 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRIM5_HUMAN (39-392): 3.48e-68: 225: 14.85
+	Hs
		717650 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Zm
		13425 B4FC97_MAIZE (1-147): 1.18e-82: 241: 76.19		A0A1D6FSN7_MAIZE (22-366): 7.02e-52: 183: 23.86
+	Hs
		1261313 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN138_HUMAN (31-190): 6.27e-46: 160: 18.68
+	Hs
		849366 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI22_HUMAN (41-392): 2.66e-43: 159: 10.50
+	Hs
		919801 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN138_HUMAN (31-190): 6.27e-46: 160: 18.68
+	Hs
		584907 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		584923 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		849377 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		COP1_HUMAN (40-326): 3.5e-39: 151: 18.31
+	Hs
		849423 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		919794 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		COP1_HUMAN (40-326): 3.5e-39: 151: 18.31
+	Hs
		1336390 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI39_HUMAN (39-392): 2e-35: 138: 13.84
+	Hs
		749252 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		749339 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		849453 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI39_HUMAN (39-392): 2e-35: 138: 13.84