HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15147886
Identification Methods	enzymatic study
Interaction Type	ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 671
+	Hs
		896436 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		RIPK1_HUMAN (1-671): 0: 610: 100.00
+	Mm
		896583 UBE2N_MOUSE (4-147): 1.92e-68: 205: 45.83		M3K7_MOUSE (4-611): 1.21e-120: 373: 19.12
+	Hs
		829062 UBE2A_HUMAN (2-144): 2.83e-70: 209: 40.56		Q9H4D1_HUMAN (14-281): 1.82e-32: 135: 34.18
+	Hs
		883463 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		RIPK4_HUMAN (14-280): 7.4e-33: 137: 34.31
+	Hs
		896542 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		Q9H4D1_HUMAN (14-281): 1.82e-32: 135: 34.18
+	Mm
		886049 UBE2N_MOUSE (4-147): 1.92e-68: 205: 45.83		RIPK2_MOUSE (55-369): 5.14e-32: 132: 29.57
+	Hs
		435592 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		IGF1R_HUMAN (20-312): 1.02e-26: 118: 31.21