HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: HERC3 (Q15034)
Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)
Gene: HERC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9575161
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 1050
+	Hs
		919741 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HERC4_HUMAN (1-1049): 0: 1067: 55.72
+	Hs
		849311 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		UBE3A_HUMAN (460-1049): 1.23e-180: 550: 28.43
+	Hs
		919710 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		UBE3A_HUMAN (460-1049): 1.23e-180: 550: 28.43
+	Hs
		1294888 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Hs
		849411 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Hs
		919827 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Hs
		125808 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		125262 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		125335 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		849444 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		919860 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		849452 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF1_HUMAN (596-1047): 4.57e-174: 529: 25.91
+	Hs
		808052 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		808078 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		849416 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		NED4L_HUMAN (606-1048): 2.42e-169: 524: 25.21
+	Hs
		919834 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		NED4L_HUMAN (606-1048): 2.42e-169: 524: 25.21
+	Hs
		849451 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF2_HUMAN (557-1047): 1.53e-170: 519: 23.66
+	Hs
		919782 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HACE1_HUMAN (414-1050): 3e-167: 516: 19.35
+	Hs
		849478 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		HERC5_HUMAN (1-206): 5.55e-50: 194: 31.82
+	Hs
		919733 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HERC1_HUMAN (22-163): 6.56e-11: 69.3: 30.82