HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	11278995, 25723849, 33637724, 33853758, 12692129, 16601690, 9575161
Identification Methods	pull down, biochemical
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 1083
+	Hs
		919732 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		849351 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		HECW1_HUMAN (248-1082): 0: 699: 20.74
+	Hs
		919762 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HECW1_HUMAN (248-1082): 0: 699: 20.74
+	Hs
		808052 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10
+	Hs
		808078 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10
+	Hs
		849311 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		919710 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		1294888 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46
+	Hs
		849411 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46
+	Hs
		919827 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46
+	Hs
		125808 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		WWP2_HUMAN (592-1081): 3.93e-177: 542: 25.10
+	Hs
		125262 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP2_HUMAN (592-1081): 3.93e-177: 542: 25.10
+	Hs
		849451 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF2_HUMAN (557-1080): 7.6e-179: 542: 22.77
+	Hs
		125335 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		WWP2_HUMAN (592-1081): 3.93e-177: 542: 25.10
+	Hs
		849452 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		849416 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		NED4L_HUMAN (572-1081): 2.17e-174: 538: 25.33
+	Hs
		849444 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP1_HUMAN (599-1081): 1.77e-174: 537: 25.66
+	Hs
		849353 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		919765 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		919782 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HACE1_HUMAN (694-1078): 3.71e-47: 185: 31.50