HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: ZNRF4 (Q8WWF5)
E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)
Gene: ZNRF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 429
+	Hs
		1262545 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		ZNRF4_HUMAN (1-429): 2.35e-137: 402: 100.00
+	Hs
		207572 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF13_HUMAN (69-415): 4.32e-80: 254: 35.29
+	Hs
		207545 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF13_HUMAN (69-415): 4.32e-80: 254: 35.29
+	Hs
		207553 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RNF13_HUMAN (69-415): 4.32e-80: 254: 35.29
+	Hs
		1332598 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN167_HUMAN (76-428): 7.13e-72: 231: 33.99
+	Hs
		849446 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN167_HUMAN (76-428): 7.13e-72: 231: 33.99
+	Hs
		1204871 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		GOLI_HUMAN (118-429): 2.7e-64: 214: 19.58
+	Hs
		849359 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		GOLI_HUMAN (118-429): 2.7e-64: 214: 19.58
+	Hs
		1356934 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN150_HUMAN (116-421): 4.6e-62: 209: 19.14
+	Hs
		849485 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN150_HUMAN (116-421): 4.6e-62: 209: 19.14
+	Hs
		849382 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN128_HUMAN (83-411): 7.87e-62: 207: 17.55
+	Hs
		1148281 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF43_HUMAN (116-427): 1.04e-45: 170: 17.12
+	Hs
		849341 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF43_HUMAN (116-427): 1.04e-45: 170: 17.12
+	Hs
		919752 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RNF43_HUMAN (116-427): 1.04e-45: 170: 17.12
+	Hs
		919766 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		SYVN1_HUMAN (143-374): 3.91e-31: 127: 13.93
+	At
		715137 UBC9_ARATH (1-147): 8.78e-82: 238: 77.55		RNG1L_ARATH (281-394): 1.32e-25: 108: 24.59
+	Hs
		849449 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN122_HUMAN (233-371): 2.53e-25: 102: 19.42
+	Hs
		1346940 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF12_HUMAN (269-360): 1.56e-20: 96: 31.92
+	Hs
		849459 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF12_HUMAN (269-360): 1.56e-20: 96: 31.92
+	Hs
		849491 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF6_HUMAN (269-358): 5.8e-16: 82.2: 26.80