HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	30017913, 17006537, 27312108, 29311602, 17069764
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E3_UbLigase_RBR~UQ_con, IBR~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 1072
+	Hs
		1290106 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		919819 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		895873 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Mm
		895978 UB2D3_MOUSE (1-147): 9.08e-81: 236: 88.44		RNF31_MOUSE (1-1072): 0: 1083: 85.54
+	Hs
		849498 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ARI1_HUMAN (600-1058): 1.52e-114: 367: 13.84
+	Hs
		312679 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Hs
		312520 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Hs
		312553 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Hs
		312528 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Dm
		639397 UBCD1_DROME (1-147): 1.87e-81: 238: 89.12		LUBEL_DROME (180-625): 2.05e-69: 257: 17.33
+	Hs
		1354303 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF14_HUMAN (657-924): 3.51e-65: 230: 14.09
+	Hs
		849474 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF14_HUMAN (657-924): 3.51e-65: 230: 14.09
+	Hs
		919891 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RNF14_HUMAN (657-924): 3.51e-65: 230: 14.09
+	Hs
		895938 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RNF14_HUMAN (657-924): 3.51e-65: 230: 14.09
+	Hs
		842095 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		R144A_HUMAN (695-926): 5.41e-59: 206: 20.33
+	Hs
		842104 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		R144A_HUMAN (695-926): 5.41e-59: 206: 20.33
+	Hs
		919876 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN19A_HUMAN (698-946): 5.63e-54: 205: 21.21
+	Hs
		919757 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN19B_HUMAN (698-946): 5.65e-42: 167: 22.43
+	Hs
		895819 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RN19B_HUMAN (698-946): 5.65e-42: 167: 22.43
+	Hs
		919893 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		ZRAN1_HUMAN (226-379): 5.88e-20: 97.7: 19.44