HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: TRI31 (Q9BZY9)
E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31)
Gene: TRIM31

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.731

Property	Details
Experiments	19549727, 34016972, 34650049, 35217669, 27929086, 21143188
Identification Methods	two hybrid, pull down, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 425
+	Hs
		1336390 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI39_HUMAN (7-378): 6.84e-96: 298: 24.81
+	Hs
		584907 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RO52_HUMAN (1-378): 3.73e-97: 300: 23.81
+	Hs
		1318532 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI31_HUMAN (1-425): 1.72e-96: 297: 100.00
+	Hs
		537142 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI27_HUMAN (1-378): 1.04e-92: 290: 23.56
+	Hs
		536760 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI27_HUMAN (1-378): 1.04e-92: 290: 23.56
+	Hs
		1318719 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRIM5_HUMAN (1-417): 6.6e-85: 269: 22.00
+	Hs
		135045 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI38_HUMAN (1-417): 1.38e-84: 268: 21.68
+	Hs
		135012 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI38_HUMAN (1-417): 1.38e-84: 268: 21.68
+	Hs
		849314 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI26_HUMAN (1-370): 6.92e-83: 265: 26.80
+	Hs
		849366 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI22_HUMAN (1-377): 7.65e-82: 261: 22.31
+	Hs
		1285831 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI43_HUMAN (1-388): 6.24e-80: 255: 22.17
+	Hs
		1204911 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI50_HUMAN (1-377): 4.55e-79: 254: 17.02
+	Hs
		849360 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI50_HUMAN (1-377): 4.55e-79: 254: 17.02
+	Hs
		1354526 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI10_HUMAN (1-357): 2.16e-75: 244: 27.96
+	Hs
		1377469 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI17_HUMAN (1-378): 1.66e-73: 239: 23.02
+	Hs
		849347 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI72_HUMAN (1-377): 8.35e-71: 232: 17.23
+	Hs
		1313765 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI62_HUMAN (6-378): 8.22e-70: 229: 19.21
+	Hs
		1357712 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRI35_HUMAN (3-367): 1.3e-68: 227: 18.92
+	Hs
		849358 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI69_HUMAN (2-388): 4.27e-69: 228: 19.49
+	Hs
		849384 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRI41_HUMAN (3-44): 2.26e-14: 77: 52.38