HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: MARH7 (Q9H992)
E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7)
Gene: MARCHF7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	24905733
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0061630 - ubiquitin protein ligase activity GO:1902916 - positive regulation of protein polyubiquitination
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 704
+	Hs
		919864 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		MARH7_HUMAN (1-704): 0: 942: 100.00
+	Hs
		895915 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		MARH7_HUMAN (1-704): 0: 942: 100.00
+	Hs
		851887 UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94		MARH7_HUMAN (1-704): 0: 942: 100.00
+	Hs
		896544 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		MARH7_HUMAN (1-704): 0: 942: 100.00
+	Hs
		1199325 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		MARH3_HUMAN (490-681): 1.84e-57: 197: 18.09
+	Hs
		919767 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		MARH3_HUMAN (490-681): 1.84e-57: 197: 18.09
+	Hs
		895832 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		MARH3_HUMAN (490-681): 1.84e-57: 197: 18.09
+	Hs
		849466 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		MARH2_HUMAN (490-681): 5.49e-52: 182: 19.60
+	Hs
		1199317 UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94		MARH3_HUMAN (490-681): 1.84e-57: 197: 18.09
+	Hs
		851833 UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94		MARH3_HUMAN (490-681): 1.84e-57: 197: 18.09
+	Hs
		849378 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		MARH1_HUMAN (490-647): 1.35e-47: 171: 22.15
+	Hs
		851897 UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94		MARH2_HUMAN (490-681): 5.49e-52: 182: 19.60
+	Hs
		849338 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		MARH8_HUMAN (505-647): 6.68e-37: 141: 20.98
+	Hs
		895806 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		MARH8_HUMAN (505-647): 6.68e-37: 141: 20.98
+	Hs
		849469 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		MARH4_HUMAN (538-647): 2.16e-27: 117: 22.52
+	Hs
		231862 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		MARH6_HUMAN (544-620): 1.64e-19: 95.7: 28.57
+	Zm
		35750 A0A1D6LTJ2_MAIZE (1-112): 2.27e-58: 180: 74.11		A0A1D6LR06_MAIZE (551-649): 5.5e-18: 90.7: 25.25