HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: APC11 (Q9NYG5)
Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)
Gene: ANAPC11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	19475398, 26329581, 32307883, 20080579, 19826003
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-ANAPC11
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 84
+	Hs
		921482 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Hs
		849303 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		895979 UB2D1_MOUSE (1-147): 3.24e-82: 239: 100.00		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Hs
		919882 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Sc
		549847 UBC4_YEAST (3-147): 3.9e-79: 232: 79.31		APC11_YEAST (1-84): 1.31e-30: 107: 41.18
+	Hs
		919703 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		919923 UB2D2_MOUSE (1-147): 7.7e-82: 238: 89.12		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Ce
		715111 UBC2_CAEEL (1-147): 7.45e-82: 239: 89.12		RBX1_CAEEL (2-84): 2.72e-28: 99.8: 37.50
+	Hs
		895932 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Hs
		895771 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		895973 UB2D3_MOUSE (1-147): 9.08e-81: 236: 88.44		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Ce
		715108 UBC2_CAEEL (1-147): 7.45e-82: 239: 89.12		APC11_CAEEL (1-84): 1.57e-26: 95.9: 45.98
+	Sp
		804461 UBC4_SCHPO (1-147): 6.75e-80: 234: 79.59		APC11_SCHPO (1-83): 8.94e-28: 97.8: 51.19
+	Hs
		1354003 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Sc
		549843 UBC4_YEAST (3-147): 3.9e-79: 232: 79.31		RBX1_YEAST (2-84): 3.85e-26: 94.4: 34.09
+	Hs
		849472 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		919890 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		895936 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		296887 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		LTN1_HUMAN (18-80): 6.02e-13: 63.9: 23.81
+	Hs
		296893 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		LTN1_HUMAN (18-80): 6.02e-13: 63.9: 23.81