HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	33961781, 33853758
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 2610
+	Hs
		1357018 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		849351 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66
+	Hs
		919762 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66
+	Hs
		304110 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		1294888 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		849416 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		849411 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		849451 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF2_HUMAN (2235-2607): 4.78e-118: 395: 20.62
+	Hs
		849452 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125808 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125262 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125335 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		849444 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		1056647 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		849331 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		919729 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		849311 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		919710 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		849334 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		UBE3C_HUMAN (2405-2610): 9.09e-23: 109: 32.37
+	Hs
		919732 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		UBE3C_HUMAN (2405-2610): 9.09e-23: 109: 32.37