HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 16307917, 19240029, 22101235, 25451919, 26330542, 26010904, 23109339, 17426036, 27903893, 28757353, 28362432, 29091030, 29898993, 32591478, 16554822, 34057440, 18485199, 17873020, 17545168, 34565360 and 27 others

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Identification Methods pull down, affinity chromatography technology, ubiquitinase assay
Interaction Type direct interaction, physical association, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains U-box~UQ_con
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 7 others

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Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 147
Hs

1 303
+ Hs
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+ Hs
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+ At
+ At
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+ Ce
+ Zm
+ Zm

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Last updated: 15 Jul 2024