HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.939

Property	Details
Experiments	32296183, 19690564, 19549727, 14562029, unassigned1304
Identification Methods	two hybrid, pull down, enzymatic study, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, ubiquitination reaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 154
+	Hs
		1377465 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		207572 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF13_HUMAN (77-146): 1.55e-26: 104: 33.80
+	Hs
		1377467 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN115_HUMAN (10-154): 2e-26: 102: 19.08
+	Hs
		207545 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF13_HUMAN (77-146): 1.55e-26: 104: 33.80
+	Hs
		1204871 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		GOLI_HUMAN (57-146): 1.98e-25: 101: 24.44
+	At
		715137 UBC9_ARATH (1-147): 8.78e-82: 238: 77.55		RNG1L_ARATH (15-153): 5.68e-27: 104: 23.61
+	Zm
		74334 B4FC97_MAIZE (1-147): 1.18e-82: 241: 76.19		B6U926_MAIZE (52-153): 2.57e-25: 101: 29.52
+	Zm
		79637 B6SZE0_MAIZE (1-147): 1.32e-82: 241: 75.51		B6U926_MAIZE (52-153): 2.57e-25: 101: 29.52
+	Hs
		849497 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN115_HUMAN (10-154): 2e-26: 102: 19.08
+	Hs
		849359 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		GOLI_HUMAN (57-146): 1.98e-25: 101: 24.44
+	Hs
		1356934 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN150_HUMAN (57-146): 3.61e-24: 98.4: 26.67
+	Hs
		849382 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		849491 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF6_HUMAN (1-149): 3.51e-24: 99.2: 20.83
+	Hs
		849485 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN150_HUMAN (57-146): 3.61e-24: 98.4: 26.67
+	At
		715158 UBC11_ARATH (1-147): 6.25e-82: 239: 76.19		RHG1A_ARATH (13-141): 1.35e-23: 97.6: 14.93
+	At
		715139 UBC9_ARATH (1-147): 8.78e-82: 238: 77.55		RHG1A_ARATH (13-141): 1.35e-23: 97.6: 14.93
+	Hs
		1346940 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		849459 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		1332598 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN167_HUMAN (77-143): 4.96e-21: 89.1: 36.77
+	Hs
		849446 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN167_HUMAN (77-143): 4.96e-21: 89.1: 36.77