HitPredict

Interactor 1: CCL11 (P51671)
Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
Gene: CCL11

Interactor 2: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.951

Property	Details
Experiments	8642344, 10733106, 25450766, 9207005, 9169459, 12218106, 23597562
Identification Methods	pull down, experimental interaction detection, nuclear magnetic resonance, competition binding, monoclonal antibody blockade, scintillation proximity assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0001938 - positive regulation of endothelial cell proliferation GO:0007155 - cell adhesion GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0045766 - positive regulation of angiogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 355
+	Hs
		561728 CL3L1_HUMAN (1-92): 5.52e-34: 113: 39.36		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		686635 CCL8_HUMAN (1-97): 7.48e-33: 111: 69.70		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		1305163 CCL13_HUMAN (1-96): 8.14e-35: 116: 64.29		ACKR4_HUMAN (10-343): 1e-85: 264: 30.09
+	Hs
		945622 CCL8_HUMAN (1-97): 7.48e-33: 111: 69.70		ACKR4_HUMAN (10-343): 1e-85: 264: 30.09
+	Mm
		486358 CCL2_MOUSE (1-97): 1.98e-34: 116: 47.48		CCR2_MOUSE (4-355): 8.41e-83: 257: 51.41
+	Hs
		849619 CCL13_HUMAN (1-96): 8.14e-35: 116: 64.29		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		561732 CL3L1_HUMAN (1-92): 5.52e-34: 113: 39.36		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		783833 CCL13_HUMAN (1-96): 8.14e-35: 116: 64.29		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Hs
		783815 CCL8_HUMAN (1-97): 7.48e-33: 111: 69.70		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Mm
		849656 CCL8_MOUSE (1-97): 5.86e-33: 111: 50.52		CCR5_MOUSE (5-355): 1.66e-77: 243: 50.70
+	Hs
		849654 CCL13_HUMAN (1-96): 8.14e-35: 116: 64.29		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		561733 CL3L1_HUMAN (1-92): 5.52e-34: 113: 39.36		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		849647 CCL8_HUMAN (1-97): 7.48e-33: 111: 69.70		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Mm
		192790 CCL2_MOUSE (1-97): 1.98e-34: 116: 47.48		CCRL2_MOUSE (44-318): 3.48e-55: 186: 38.79
+	Hs
		134400 CCL13_HUMAN (1-96): 8.14e-35: 116: 64.29		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134369 CCL11_HUMAN (1-97): 5.99e-33: 111: 100.00		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134373 CCL8_HUMAN (1-97): 7.48e-33: 111: 69.70		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Mm
		139696 CCL2_MOUSE (1-97): 1.98e-34: 116: 47.48		ACKR2_MOUSE (16-343): 1.57e-46: 164: 34.55
+	Mm
		291526 CCL11_MOUSE (1-97): 5.22e-36: 119: 58.76		CXCR3_MOUSE (36-318): 4.07e-45: 160: 36.36
+	Hs
		830629 CCL13_HUMAN (1-96): 8.14e-35: 116: 64.29		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36