HitPredict

Interactor 1: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Interactor 2: CCL7 (P80098)
C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
Gene: CCL7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.785

Property	Details
Experiments	8642344, 10733106
Identification Methods	pull down, experimental interaction detection, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 99
+	Mm
		500591 CCR3_MOUSE (9-355): 3.86e-90: 276: 70.03		CCL3_MOUSE (1-94): 3.69e-35: 117: 37.23
+	Hs
		561728 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CL3L1_HUMAN (1-94): 5.46e-36: 119: 36.17
+	Hs
		526560 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL4_HUMAN (1-93): 5.91e-35: 116: 37.63
+	Hs
		686636 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00
+	Hs
		686635 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL8_HUMAN (1-98): 1.56e-34: 115: 65.31
+	Hs
		528201 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL2_HUMAN (1-98): 1.52e-33: 113: 74.49
+	Hs
		686667 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL14_HUMAN (1-93): 1.02e-33: 113: 31.92
+	Hs
		486230 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL3_HUMAN (1-94): 6.43e-33: 111: 34.04
+	Mm
		534669 CCR3_MOUSE (9-355): 3.86e-90: 276: 70.03		CCL4_MOUSE (1-93): 9.46e-30: 103: 35.48
+	Hs
		686626 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL23_HUMAN (1-98): 1.72e-27: 98.5: 30.83
+	Hs
		686668 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL15_HUMAN (1-91): 2.29e-26: 95.4: 30.00
+	Hs
		607526 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL1_HUMAN (1-98): 2.89e-26: 94.7: 33.67
+	Mm
		486212 CCR8_MOUSE (1-335): 1.93e-91: 279: 37.57		CCL1_MOUSE (1-90): 1.05e-23: 88.1: 30.00
+	Hs
		528244 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL5_HUMAN (1-92): 1.86e-25: 92.4: 34.78
+	Hs
		607528 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL1_HUMAN (1-98): 2.89e-26: 94.7: 33.67
+	Hs
		849723 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL18_HUMAN (1-94): 3.16e-26: 94.3: 35.11
+	Hs
		180158 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL16_HUMAN (1-89): 3.36e-23: 87.7: 33.70
+	Hs
		180162 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL16_HUMAN (1-89): 3.36e-23: 87.7: 33.70
+	Hs
		849725 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL17_HUMAN (6-91): 9.53e-23: 85.8: 34.88
+	Hs
		134312 ACKR4_HUMAN (10-343): 1e-85: 264: 30.09		CCL21_HUMAN (33-98): 2.48e-18: 75.4: 36.23