HitPredict

Interactor 1: CCR4 (P51679)
C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
Gene: CCR4

Interactor 2: CCL17 (Q92583)
C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
Gene: CCL17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	10488147, 9169459, 9169480, 9430724, 10498628, 28381538
Identification Methods	experimental interaction detection, biochemical, saturation binding, fluorescence-activated cell sorting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 94
+	Hs
		134400 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL13_HUMAN (6-94): 5.69e-34: 113: 29.21
+	Hs
		134356 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL4_HUMAN (4-91): 1.63e-33: 112: 27.27
+	Hs
		486238 CCR4_HUMAN (1-360): 2.26e-90: 277: 100.00		CCL3_HUMAN (3-92): 7.79e-31: 105: 26.37
+	Hs
		134373 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL8_HUMAN (15-94): 8.16e-31: 106: 23.46
+	Hs
		134374 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL7_HUMAN (16-94): 7.08e-31: 106: 30.00
+	Hs
		134380 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL14_HUMAN (1-91): 5.9e-31: 106: 29.67
+	Hs
		134354 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL3_HUMAN (3-92): 7.79e-31: 105: 26.37
+	Mm
		139696 ACKR2_MOUSE (3-351): 4.29e-86: 266: 35.61		CCL2_MOUSE (3-92): 7.21e-33: 112: 28.57
+	Hs
		134357 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL2_HUMAN (15-94): 6.73e-29: 101: 23.46
+	Mm
		139697 ACKR2_MOUSE (3-351): 4.29e-86: 266: 35.61		CCL4_MOUSE (16-91): 2.68e-30: 104: 27.63
+	Hs
		134369 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL11_HUMAN (16-94): 4.16e-27: 96.6: 30.00
+	Hs
		825305 CX3C1_HUMAN (9-355): 4.62e-88: 270: 41.57		X3CL1_HUMAN (1-92): 1.76e-25: 98.9: 28.42
+	Hs
		528253 CCR4_HUMAN (1-360): 2.26e-90: 277: 100.00		CCL5_HUMAN (14-90): 3.37e-25: 91.6: 25.97
+	Hs
		134358 ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30		CCL5_HUMAN (14-90): 3.37e-25: 91.6: 25.97
+	Mm
		486358 CCR2_MOUSE (18-360): 1.65e-80: 252: 47.67		CCL2_MOUSE (3-92): 7.21e-33: 112: 28.57
+	Hs
		526560 CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11		CCL4_HUMAN (4-91): 1.63e-33: 112: 27.27
+	Hs
		134728 CCR4_HUMAN (1-360): 2.26e-90: 277: 100.00		CCL22_HUMAN (22-90): 1.14e-21: 82.7: 32.86
+	Hs
		486230 CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11		CCL3_HUMAN (3-92): 7.79e-31: 105: 26.37
+	Mm
		849658 CCR2_MOUSE (18-360): 1.65e-80: 252: 47.67		CCL7_MOUSE (16-94): 6.36e-23: 86.2: 31.25
+	Hs
		180158 CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11		CCL16_HUMAN (24-87): 1.37e-21: 83.5: 29.69