HitPredict

Interactor 1: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Interactor 2: CCL7 (P80098)
C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
Gene: CCL7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10477718
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007186 - G protein-coupled receptor signaling pathway GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 99
+	Mm
		486358 CCR2_MOUSE (9-352): 3.95e-85: 263: 74.71		CCL2_MOUSE (1-94): 2.82e-36: 121: 53.19
+	Hs
		849654 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27
+	Hs
		561733 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CL3L1_HUMAN (1-94): 5.46e-36: 119: 36.17
+	Hs
		1305163 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27
+	Hs
		526565 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL4_HUMAN (1-93): 5.91e-35: 116: 37.63
+	Hs
		849647 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL8_HUMAN (1-98): 1.56e-34: 115: 65.31
+	Hs
		528211 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL2_HUMAN (1-98): 1.52e-33: 113: 74.49
+	Hs
		486239 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL3_HUMAN (1-94): 6.43e-33: 111: 34.04
+	Hs
		945630 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00
+	Hs
		945622 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL8_HUMAN (1-98): 1.56e-34: 115: 65.31
+	Hs
		528225 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL2_HUMAN (1-98): 1.52e-33: 113: 74.49
+	Hs
		849505 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL11_HUMAN (1-98): 5.32e-31: 106: 69.39
+	Mm
		849656 CCR5_MOUSE (1-352): 3.08e-84: 260: 81.92		CCL8_MOUSE (1-98): 9.19e-31: 106: 45.92
+	Mm
		534670 CCR5_MOUSE (1-352): 3.08e-84: 260: 81.92		CCL4_MOUSE (1-93): 9.46e-30: 103: 35.48
+	Mm
		849658 CCR2_MOUSE (9-352): 3.95e-85: 263: 74.71		CCL7_MOUSE (1-98): 4.11e-27: 97: 62.25
+	Hs
		528254 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL5_HUMAN (1-92): 1.86e-25: 92.4: 34.78
+	Hs
		180161 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL16_HUMAN (1-89): 3.36e-23: 87.7: 33.70
+	Hs
		849653 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL17_HUMAN (6-91): 9.53e-23: 85.8: 34.88
+	Hs
		134312 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL21_HUMAN (33-98): 2.48e-18: 75.4: 36.23
+	Hs
		179471 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL25_HUMAN (8-95): 4.49e-18: 75.4: 27.37