HitPredict

Interactor 1: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Interactor 2: CCL17 (Q92583)
C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
Gene: CCL17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28381538
Identification Methods	fluorescence-activated cell sorting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007186 - G protein-coupled receptor signaling pathway GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 94
+	Mm
		486358 CCR2_MOUSE (9-352): 3.95e-85: 263: 74.71		CCL2_MOUSE (3-92): 7.21e-33: 112: 28.57
+	Hs
		849654 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL13_HUMAN (6-94): 5.69e-34: 113: 29.21
+	Hs
		526565 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL4_HUMAN (4-91): 1.63e-33: 112: 27.27
+	Hs
		561733 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CL3L1_HUMAN (3-92): 3.23e-32: 109: 27.17
+	Hs
		1305163 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL13_HUMAN (6-94): 5.69e-34: 113: 29.21
+	Hs
		849647 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL8_HUMAN (15-94): 8.16e-31: 106: 23.46
+	Hs
		849648 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL7_HUMAN (16-94): 7.08e-31: 106: 30.00
+	Hs
		486239 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL3_HUMAN (3-92): 7.79e-31: 105: 26.37
+	Mm
		534670 CCR5_MOUSE (1-352): 3.08e-84: 260: 81.92		CCL4_MOUSE (16-91): 2.68e-30: 104: 27.63
+	Hs
		528211 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL2_HUMAN (15-94): 6.73e-29: 101: 23.46
+	Hs
		945622 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL8_HUMAN (15-94): 8.16e-31: 106: 23.46
+	Hs
		945630 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL7_HUMAN (16-94): 7.08e-31: 106: 30.00
+	Hs
		849505 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL11_HUMAN (16-94): 4.16e-27: 96.6: 30.00
+	Hs
		528225 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL2_HUMAN (15-94): 6.73e-29: 101: 23.46
+	Hs
		528254 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL5_HUMAN (14-90): 3.37e-25: 91.6: 25.97
+	Mm
		849656 CCR5_MOUSE (1-352): 3.08e-84: 260: 81.92		CCL8_MOUSE (6-93): 4.96e-25: 91.2: 28.09
+	Mm
		849658 CCR2_MOUSE (9-352): 3.95e-85: 263: 74.71		CCL7_MOUSE (16-94): 6.36e-23: 86.2: 31.25
+	Hs
		179471 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL25_HUMAN (4-93): 4.24e-25: 93.1: 23.96
+	Hs
		180161 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL16_HUMAN (24-87): 1.37e-21: 83.5: 29.69
+	Hs
		134312 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL21_HUMAN (30-93): 4.84e-18: 74.6: 25.00