HitPredict

Interactor 1: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Interactor 2: CCL13 (Q99616)
C-C motif chemokine 13 (CK-beta-10) (Monocyte chemoattractant protein 4) (Monocyte chemotactic protein 4) (MCP-4) (NCC-1) (Small-inducible cytokine A13) [Cleaved into: C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain]
Gene: CCL13

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10477718
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007186 - G protein-coupled receptor signaling pathway GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 98
+	Hs
		1305163 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL13_HUMAN (1-98): 4.86e-39: 126: 100.00
+	Hs
		561733 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CL3L1_HUMAN (1-93): 1.3e-36: 120: 41.94
+	Hs
		526565 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL4_HUMAN (1-92): 6.96e-36: 118: 39.13
+	Mm
		486358 CCR2_MOUSE (9-352): 3.95e-85: 263: 74.71		CCL2_MOUSE (1-93): 3.22e-33: 113: 54.26
+	Hs
		486239 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL3_HUMAN (1-93): 1.45e-33: 113: 38.71
+	Hs
		849647 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL8_HUMAN (1-97): 3.41e-32: 109: 62.25
+	Hs
		528211 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL2_HUMAN (1-98): 6.78e-31: 106: 64.65
+	Mm
		534670 CCR5_MOUSE (1-352): 3.08e-84: 260: 81.92		CCL4_MOUSE (1-92): 7.96e-31: 106: 39.13
+	Hs
		849648 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL7_HUMAN (17-97): 1.05e-30: 105: 60.98
+	Hs
		945622 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL8_HUMAN (1-97): 3.41e-32: 109: 62.25
+	Hs
		528225 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL2_HUMAN (1-98): 6.78e-31: 106: 64.65
+	Hs
		849505 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL11_HUMAN (1-97): 2.03e-28: 100: 64.29
+	Mm
		849656 CCR5_MOUSE (1-352): 3.08e-84: 260: 81.92		CCL8_MOUSE (1-97): 1.41e-28: 100: 46.94
+	Hs
		945630 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL7_HUMAN (17-97): 1.05e-30: 105: 60.98
+	Hs
		528254 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL5_HUMAN (1-91): 4.66e-27: 96.6: 31.87
+	Mm
		849658 CCR2_MOUSE (9-352): 3.95e-85: 263: 74.71		CCL7_MOUSE (1-97): 1.02e-24: 90.8: 52.04
+	Hs
		849653 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL17_HUMAN (7-90): 1.94e-25: 92.3: 30.95
+	Hs
		180161 CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00		CCL16_HUMAN (1-88): 8.65e-22: 83.9: 34.07
+	Hs
		134312 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL21_HUMAN (24-97): 1.18e-17: 73.8: 29.49
+	Hs
		179471 ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35		CCL25_HUMAN (7-94): 2.85e-17: 73.1: 24.47