HitPredict

Interactor 1: CCR8 (P51685)
C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198)
Gene: CCR8

Interactor 2: CCL18 (P55774)
C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]
Gene: CCL18

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23999500
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006955 - immune response GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 89
+	Hs
		561732 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CL3L1_HUMAN (1-89): 2.5e-34: 114: 59.14
+	Hs
		486237 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL3_HUMAN (1-89): 8.49e-34: 113: 60.87
+	Hs
		849619 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL13_HUMAN (1-89): 1.89e-33: 112: 34.41
+	Hs
		526564 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL4_HUMAN (1-88): 1.39e-32: 109: 42.39
+	Hs
		849613 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL18_HUMAN (1-89): 5.19e-32: 108: 100.00
+	Hs
		849616 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL14_HUMAN (1-88): 2.5e-31: 106: 41.94
+	Hs
		849617 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL15_HUMAN (1-86): 1.12e-27: 98.4: 36.70
+	Hs
		849504 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL11_HUMAN (1-89): 7.03e-27: 95.7: 34.78
+	Hs
		528252 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL5_HUMAN (1-88): 1.85e-26: 94.6: 38.46
+	Hs
		849614 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL7_HUMAN (1-89): 4.28e-26: 93.8: 31.92
+	Hs
		528210 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL2_HUMAN (1-89): 5.39e-26: 93.4: 30.85
+	Hs
		118813 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL24_HUMAN (1-88): 5.56e-25: 91.5: 32.58
+	Hs
		134354 ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33		CCL3_HUMAN (1-89): 8.49e-34: 113: 60.87
+	Hs
		849620 CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64		CCL26_HUMAN (18-86): 8.66e-24: 88: 39.13
+	Hs
		134356 ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33		CCL4_HUMAN (1-88): 1.39e-32: 109: 42.39
+	Hs
		825305 CX3C1_HUMAN (5-350): 5.91e-86: 265: 38.91		X3CL1_HUMAN (8-89): 2.18e-22: 90.4: 26.97
+	Hs
		134373 ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33		CCL8_HUMAN (1-87): 1.58e-28: 99: 31.52
+	Hs
		134369 ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33		CCL11_HUMAN (1-89): 7.03e-27: 95.7: 34.78
+	Hs
		134358 ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33		CCL5_HUMAN (1-88): 1.85e-26: 94.6: 38.46
+	Hs
		134357 ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33		CCL2_HUMAN (1-89): 5.39e-26: 93.4: 30.85