HitPredict

Interactor 1: STA5B (P51692)
Signal transducer and activator of transcription 5B
Gene: STAT5B

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9742102
Identification Methods	electrophoretic mobility shift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SOCS_box
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 787 Hs			1 258
+	Hs
		146609 STA5B_HUMAN (1-787): 0: 1106: 100.00		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		786637 STA5A_HUMAN (1-779): 0: 1060: 93.84		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Mm
		786656 STA5A_MOUSE (1-779): 0: 1049: 91.91		CISH_MOUSE (1-258): 3.74e-69: 215: 90.31
+	Hs
		146672 STA5A_HUMAN (1-779): 0: 1060: 93.84		SOCS7_HUMAN (43-256): 3.74e-43: 155: 25.93
+	Hs
		849884 STA5B_HUMAN (1-787): 0: 1106: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		849903 STA5B_HUMAN (1-787): 0: 1106: 100.00		P55G_HUMAN (53-183): 1.06e-21: 95.3: 15.27
+	Hs
		786601 STA5A_HUMAN (1-779): 0: 1060: 93.84		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Mm
		719288 STA5A_MOUSE (1-779): 0: 1049: 91.91		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		522836 STAT1_HUMAN (1-707): 0: 763: 29.44		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		147400 STAT3_HUMAN (1-724): 0: 754: 30.22		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		256851 STAT1_HUMAN (1-707): 0: 763: 29.44		SOCS5_HUMAN (59-257): 3.09e-41: 149: 25.87
+	Hs
		146671 STAT3_HUMAN (1-724): 0: 754: 30.22		SOCS7_HUMAN (43-256): 3.74e-43: 155: 25.93
+	Mm
		403422 STAT3_MOUSE (1-724): 0: 755: 30.22		SRC_MOUSE (50-248): 7.06e-42: 151: 16.11
+	Hs
		412065 STAT3_HUMAN (1-724): 0: 754: 30.22		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		442788 STAT3_HUMAN (1-724): 0: 754: 30.22		HCK_HUMAN (47-215): 1.32e-41: 150: 15.82
+	Hs
		411624 STAT3_HUMAN (1-724): 0: 754: 30.22		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Mm
		193377 STAT3_MOUSE (1-724): 0: 755: 30.22		SOCS3_MOUSE (43-254): 1.24e-40: 141: 29.77
+	Hs
		786325 STAT1_HUMAN (1-707): 0: 763: 29.44		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		129229 STAT3_HUMAN (1-724): 0: 754: 30.22		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		433628 STAT3_HUMAN (1-724): 0: 754: 30.22		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21