HitPredict

Interactor 1: APLP1 (P51693)
Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]
Gene: APLP1

Interactor 2: APLP1 (P51693)
Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]
Gene: APLP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 21930949, 16193067
Identification Methods x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains APP_Cu_bd~APP_Cu_bd, APP_Cu_bd~APP_N, APP_E2~APP_E2, APP_N~APP_N
Common GO terms GO:0005604 - basement membrane
GO:0005654 - nucleoplasm
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
GO:0006417 - regulation of translation
and 18 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 650
Hs

1 650
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
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+ Dm

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Last updated: 15 Jul 2024