HitPredict

Interactor 1: UBP11 (P51784)
Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11)
Gene: USP11

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	28040451, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 963 Hs			1 497
+	Hs
		957751 UBP7_HUMAN (607-959): 9.02e-54: 205: 15.17		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		301374 UBP19_HUMAN (496-656): 3.05e-21: 102: 7.96		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Mm
		1141990 UBP15_MOUSE (493-644): 8.98e-18: 90.8: 10.06		XIAP_MOUSE (1-497): 0: 544: 88.73
+	Hs
		1036312 UBP7_HUMAN (607-959): 9.02e-54: 205: 15.17		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		1174178 UBP43_HUMAN (285-938): 2.36e-115: 382: 23.78		RFFL_HUMAN (446-497): 3.49e-18: 88: 44.23
+	Hs
		1257022 UBP33_HUMAN (223-945): 9.3e-109: 360: 18.55		CGRF1_HUMAN (317-491): 2.2e-23: 102: 14.29
+	Hs
		301386 UBP19_HUMAN (496-656): 3.05e-21: 102: 7.96		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		1035953 UBP7_HUMAN (607-959): 9.02e-54: 205: 15.17		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		271165 UBP2_HUMAN (609-936): 9.85e-61: 220: 23.37		BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83
+	Hs
		1036377 UBP15_HUMAN (485-644): 1.32e-17: 90.4: 10.18		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		777082 UBP8_HUMAN (597-939): 3.73e-58: 219: 23.28		BIRC6_HUMAN (258-442): 3.1e-26: 115: 18.78
+	Hs
		271121 UBP2_HUMAN (609-936): 9.85e-61: 220: 23.37		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		271156 UBP2_HUMAN (609-936): 9.85e-61: 220: 23.37		MYLIP_HUMAN (430-496): 3.78e-23: 103: 35.82
+	Hs
		177733 UBP22_HUMAN (597-930): 2.39e-62: 222: 17.88		BIRC5_HUMAN (266-372): 1.61e-21: 92.3: 26.32
+	Hs
		1264871 UBP7_HUMAN (607-959): 9.02e-54: 205: 15.17		RFFL_HUMAN (446-497): 3.49e-18: 88: 44.23
+	Hs
		1165224 UBP21_HUMAN (778-935): 1.96e-48: 183: 38.61		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		301385 UBP19_HUMAN (496-656): 3.05e-21: 102: 7.96		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		1036241 UBP15_HUMAN (485-644): 1.32e-17: 90.4: 10.18		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		177638 UBP19_HUMAN (496-656): 3.05e-21: 102: 7.96		BIRC5_HUMAN (266-372): 1.61e-21: 92.3: 26.32
+	Hs
		1206095 UBP15_HUMAN (485-644): 1.32e-17: 90.4: 10.18		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68