HitPredict

Interactor 1: KCNQ1 (P51787)
Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
Gene: KCNQ1

Interactor 2: AKAP9 (Q99996)
A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao)
Gene: AKAP9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

The method score is based on:

Property	Details
Experiments	18093912, 24713462, 11799244
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008076 - voltage-gated potassium channel complex GO:0034237 - protein kinase A regulatory subunit binding GO:0043025 - neuronal cell body GO:0044325 - transmembrane transporter binding GO:0060306 - regulation of membrane repolarization and 3 others more... GO:0060307 - regulation of ventricular cardiac muscle cell membrane repolarization GO:0071320 - cellular response to cAMP GO:0086091 - regulation of heart rate by cardiac conduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	676
Hs

1	3907

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024