HitPredict

Interactor 1: VAMP7 (P51809)
Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)
Gene: VAMP7

Interactor 2: STX12 (Q86Y82)
Syntaxin-12
Gene: STX12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0006906 - vesicle fusion GO:0031201 - SNARE complex GO:0043231 - intracellular membrane-bounded organelle and 1 others more... GO:0045335 - phagocytic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 220 Hs			1 276
+	Rn
		699183 VAMP7_RAT (1-220): 2.58e-90: 266: 95.00		STX1A_RAT (18-273): 3.22e-67: 212: 24.05
+	Hs
		850569 VAMP7_HUMAN (1-220): 3.87e-90: 266: 100.00		STX1A_HUMAN (17-273): 6.81e-67: 211: 23.19
+	At
		1352985 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SYP42_ARATH (2-273): 1.6e-59: 193: 21.79
+	At
		1378372 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SY121_ARATH (8-252): 2.96e-59: 193: 18.75
+	Mm
		936372 VAMP7_MOUSE (1-220): 8.73e-89: 262: 97.27		Q8BH40_MOUSE (8-272): 2.98e-63: 201: 51.70
+	At
		955702 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		812702 VA722_ARATH (2-215): 1.46e-90: 267: 35.65		SY121_ARATH (8-252): 2.96e-59: 193: 18.75
+	At
		249598 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SYP41_ARATH (2-273): 4.62e-58: 189: 21.07
+	At
		1352937 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SY122_ARATH (1-252): 6.92e-57: 187: 20.53
+	At
		955681 VA713_ARATH (1-219): 1.74e-90: 266: 38.01		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		1352876 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SYP43_ARATH (2-273): 2.11e-55: 183: 20.00
+	Hs
		178445 VAMP7_HUMAN (1-220): 3.87e-90: 266: 100.00		STX7_HUMAN (8-272): 1.12e-55: 181: 51.70
+	At
		955679 VA714_ARATH (1-217): 1.84e-85: 254: 41.10		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		221561 VA711_ARATH (1-218): 2.1e-85: 253: 40.18		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	Hs
		850561 VAMP7_HUMAN (1-220): 3.87e-90: 266: 100.00		STX4_HUMAN (6-272): 1.25e-53: 177: 24.27
+	At
		1114744 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SY111_ARATH (4-252): 1.64e-51: 172: 19.77
+	Hs
		850562 VAMP7_HUMAN (1-220): 3.87e-90: 266: 100.00		STX3_HUMAN (5-250): 2.56e-53: 176: 25.20
+	At
		812689 VA722_ARATH (2-215): 1.46e-90: 267: 35.65		SY111_ARATH (4-252): 1.64e-51: 172: 19.77
+	At
		221563 VA711_ARATH (1-218): 2.1e-85: 253: 40.18		SYP21_ARATH (1-258): 7.63e-55: 180: 27.88
+	At
		1258650 VA721_ARATH (2-214): 6.9e-92: 270: 36.74		SY132_ARATH (107-252): 5.34e-12: 66.6: 32.88