HitPredict

Interactor 1: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Interactor 2: CSK2B (P67870)
Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)
Gene: CSNK2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.944

Property	Details
Experiments	33961781, 31980649, 35271311, 32707033, unassigned2173, 10094392
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CK_II_beta~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 740 Hs			1 215
+	Hs
		931650 KS6A1_HUMAN (1-740): 0: 783: 77.90		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		270398 KS6A5_HUMAN (47-734): 0: 703: 40.86		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		272858 KS6A4_HUMAN (59-739): 0: 646: 40.81		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		931918 KS6B2_HUMAN (419-727): 5.97e-118: 364: 29.66		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		616695 KS6B1_HUMAN (397-727): 8.14e-116: 361: 25.50		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		931649 KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Dm
		437155 Q9VR61_DROME (2-328): 3.5e-90: 304: 23.68		CSK2B_DROME (1-215): 1.94e-134: 378: 88.37