HitPredict

Interactor 1: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Interactor 2: H90B2 (Q58FF8)
Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb)
Gene: HSP90AB2P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned2173
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 740 Hs			1 381
+	Hs
		1073431 KS6A1_HUMAN (1-740): 0: 783: 77.90		H90B2_HUMAN (1-381): 2.81e-170: 482: 100.00
+	Hs
		438011 KS6A3_HUMAN (1-740): 0: 844: 100.00		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		270422 KS6A5_HUMAN (47-734): 0: 703: 40.86		HS904_HUMAN (57-381): 4.72e-80: 253: 37.27
+	Hs
		431672 KS6A3_HUMAN (1-740): 0: 844: 100.00		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		438193 KS6A1_HUMAN (1-740): 0: 783: 77.90		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		272878 KS6A4_HUMAN (59-739): 0: 646: 40.81		HS904_HUMAN (57-381): 4.72e-80: 253: 37.27
+	Hs
		438601 KS6A6_HUMAN (1-740): 0: 771: 76.54		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		431876 KS6A1_HUMAN (1-740): 0: 783: 77.90		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		432343 KS6A6_HUMAN (1-740): 0: 771: 76.54		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		272877 KS6A4_HUMAN (59-739): 0: 646: 40.81		HS905_HUMAN (108-355): 1.06e-55: 187: 60.08
+	Hs
		270364 KS6A5_HUMAN (47-734): 0: 703: 40.86		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		270363 KS6A5_HUMAN (47-734): 0: 703: 40.86		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		272876 KS6A4_HUMAN (59-739): 0: 646: 40.81		H90B4_HUMAN (109-247): 1.76e-32: 129: 75.54
+	Hs
		272844 KS6A4_HUMAN (59-739): 0: 646: 40.81		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		272843 KS6A4_HUMAN (59-739): 0: 646: 40.81		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Mm
		513660 AKT1_MOUSE (327-739): 6.45e-126: 385: 21.02		HS90B_MOUSE (109-251): 9.78e-33: 131: 86.71
+	Hs
		437928 AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Bt
		964601 AKT1_BOVIN (413-739): 5.92e-126: 385: 24.78		HS90B_BOVIN (109-251): 8.91e-32: 128: 87.41
+	Hs
		431573 AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Mm
		432411 AKT1_MOUSE (327-739): 6.45e-126: 385: 21.02		HS90A_MOUSE (87-251): 1.56e-26: 113: 59.41