HitPredict

Interactor 1: PRKX (P51817)
cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)
Gene: PRKX

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	32707033, 33961781
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 505
+	Hs
		217856 PRKY_HUMAN (1-272): 0: 506: 92.28		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438013 PRKX_HUMAN (1-358): 5.47e-155: 441: 100.00		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437928 AKT2_HUMAN (11-351): 7.4e-153: 440: 38.66		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437907 KPCL_HUMAN (7-358): 6.61e-150: 439: 31.22		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438633 AKT3_HUMAN (7-355): 4.72e-152: 438: 37.78		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Mm
		513660 AKT1_MOUSE (11-351): 6.46e-151: 435: 37.97		HS90B_MOUSE (1-504): 0: 673: 70.11
+	Bt
		964601 AKT1_BOVIN (11-351): 2.03e-151: 436: 37.97		HS90B_BOVIN (1-504): 0: 670: 69.76
+	Hs
		437927 AKT1_HUMAN (11-351): 1.63e-150: 434: 37.68		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431674 PRKX_HUMAN (1-358): 5.47e-155: 441: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431573 AKT2_HUMAN (11-351): 7.4e-153: 440: 38.66		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431548 KPCL_HUMAN (7-358): 6.61e-150: 439: 31.22		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		432376 AKT3_HUMAN (7-355): 4.72e-152: 438: 37.78		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431572 AKT1_HUMAN (11-351): 1.63e-150: 434: 37.68		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Rn
		812703 AKT1_RAT (11-351): 6.75e-151: 435: 38.26		HS90A_RAT (1-504): 0: 654: 61.98
+	Mm
		432411 AKT1_MOUSE (11-351): 6.46e-151: 435: 37.97		HS90A_MOUSE (1-504): 0: 652: 61.81
+	Hs
		1123447 AKT3_HUMAN (7-355): 4.72e-152: 438: 37.78		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		538446 AKT3_HUMAN (7-355): 4.72e-152: 438: 37.78		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Hs
		538122 AKT1_HUMAN (11-351): 1.63e-150: 434: 37.68		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Hs
		1123464 AKT3_HUMAN (7-355): 4.72e-152: 438: 37.78		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87
+	Hs
		1162538 AKT3_HUMAN (7-355): 4.72e-152: 438: 37.78		Q6PK50_HUMAN (1-301): 1.17e-138: 405: 80.26