HitPredict

Interactor 1: HDGF (P51858)
Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)
Gene: HDGF

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21907836
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 240 Hs			1 372
+	Hs
		260805 HDGF_HUMAN (1-240): 4.63e-53: 173: 100.00		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260808 MSH6_HUMAN (5-232): 3.82e-46: 165: 18.55		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		1115591 GLYR1_HUMAN (6-228): 2.27e-46: 163: 25.94		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		261039 ZMYD8_HUMAN (3-233): 1.74e-41: 152: 20.59		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		1349695 ZMYD8_HUMAN (3-233): 1.74e-41: 152: 20.59		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		260680 PSIP1_HUMAN (7-239): 7.38e-38: 140: 37.60		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		261003 NSD3_HUMAN (8-222): 4.17e-37: 140: 16.74		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		261029 DNM3B_HUMAN (8-211): 4.18e-31: 122: 14.49		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260919 HDGR2_HUMAN (7-222): 6.08e-26: 107: 36.57		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		555365 MSH6_HUMAN (5-232): 3.82e-46: 165: 18.55		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		855539 MSH6_HUMAN (5-232): 3.82e-46: 165: 18.55		H2A1J_HUMAN (1-125): 2.23e-64: 202: 60.94
+	Hs
		391730 GLYR1_HUMAN (6-228): 2.27e-46: 163: 25.94		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		555690 ZMYD8_HUMAN (3-233): 1.74e-41: 152: 20.59		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		391965 ZMYD8_HUMAN (3-233): 1.74e-41: 152: 20.59		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Mm
		650197 PSIP1_MOUSE (7-239): 3.58e-35: 132: 36.82		H2AX_MOUSE (1-144): 4.61e-65: 204: 56.46
+	Hs
		331860 NSD2_HUMAN (9-226): 4.97e-34: 131: 19.18		H2A1C_HUMAN (1-126): 2.96e-64: 202: 61.24
+	Hs
		331703 NSD2_HUMAN (9-226): 4.97e-34: 131: 19.18		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Hs
		331824 NSD2_HUMAN (9-226): 4.97e-34: 131: 19.18		H2A2C_HUMAN (1-126): 7.57e-64: 201: 61.24
+	Hs
		555674 DNM3B_HUMAN (8-211): 4.18e-31: 122: 14.49		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		555526 HDGR2_HUMAN (7-222): 6.08e-26: 107: 36.57		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14