HitPredict

Interactor 1: NEK2 (P51955)
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)
Gene: NEK2

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 407
+	Hs
		851306 NEK2_HUMAN (1-445): 5.46e-146: 425: 100.00		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Rn
		871314 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		Q6P3V8_RAT (3-407): 2.35e-159: 456: 89.88
+	Rn
		871308 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		Q6AYI1_RAT (22-407): 5.74e-132: 393: 30.96
+	Hs
		571423 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Rn
		2898 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		A0A0G2K719_RAT (2-406): 4.06e-128: 385: 29.51
+	Rn
		89014 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		D4ADE8_RAT (2-406): 6.57e-128: 385: 29.51
+	Rn
		871269 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		IF4A3_RAT (3-407): 1.87e-130: 383: 67.65
+	Hs
		134008 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		851620 NEK4_HUMAN (8-271): 2.82e-49: 181: 40.91		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		1173329 NEK10_HUMAN (7-275): 5.22e-37: 146: 32.98		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		571497 NEK10_HUMAN (7-275): 5.22e-37: 146: 32.98		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30