HitPredict

Interactor 1: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25798074, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 841 Hs			1 247
+	Hs
		851417 NEK4_HUMAN (1-841): 0: 617: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		683217 NEK4_HUMAN (1-841): 0: 617: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		851437 NEK4_HUMAN (1-841): 0: 617: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		683913 NEK4_HUMAN (1-841): 0: 617: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Mm
		910231 MARK3_MOUSE (3-718): 1.19e-150: 462: 19.13		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Hs
		647862 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Xl
		223344 Q804T2_XENLA (3-718): 1.88e-150: 460: 18.38		O57468_XENLA (1-244): 4.25e-141: 397: 63.12
+	Mm
		905331 MARK3_MOUSE (3-718): 1.19e-150: 462: 19.13		1433G_MOUSE (1-247): 3.15e-139: 392: 100.00
+	Hs
		647860 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Mm
		910234 MARK2_MOUSE (3-718): 6.32e-146: 450: 18.33		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Mm
		935481 MARK3_MOUSE (3-718): 1.19e-150: 462: 19.13		1433F_MOUSE (1-246): 1.51e-136: 385: 86.99
+	Hs
		647879 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Mm
		905332 MARK2_MOUSE (3-718): 6.32e-146: 450: 18.33		1433G_MOUSE (1-247): 3.15e-139: 392: 100.00
+	Mm
		935483 MARK2_MOUSE (3-718): 6.32e-146: 450: 18.33		1433F_MOUSE (1-246): 1.51e-136: 385: 86.99
+	Hs
		647835 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Mm
		926780 MARK3_MOUSE (3-718): 1.19e-150: 462: 19.13		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Mm
		975157 MARK3_MOUSE (3-718): 1.19e-150: 462: 19.13		1433B_MOUSE (2-247): 8.57e-109: 315: 75.81
+	Hs
		647869 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646650 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		647836 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16