HitPredict

Interactor 1: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Interactor 2: ROA0 (Q13151)
Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0)
Gene: HNRNPA0

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	25798074
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 841 Hs			1 305
+	Hs
		609769 NEK4_HUMAN (1-841): 0: 617: 100.00		ROA2_HUMAN (2-297): 6.2e-78: 242: 42.42
+	Hs
		851480 NEK4_HUMAN (1-841): 0: 617: 100.00		PABP4_HUMAN (5-185): 2.85e-44: 161: 19.67
+	Hs
		453228 NEK4_HUMAN (1-841): 0: 617: 100.00		ROA1_HUMAN (85-183): 1.84e-26: 108: 33.33
+	Hs
		851393 NEK4_HUMAN (1-841): 0: 617: 100.00		ROA3_HUMAN (89-183): 5.41e-23: 99.3: 34.74
+	Hs
		851491 NEK4_HUMAN (1-841): 0: 617: 100.00		HNRPD_HUMAN (3-83): 6.84e-16: 78.8: 28.40
+	Hs
		610090 KS6B2_HUMAN (6-405): 5.48e-130: 399: 21.79		ROA2_HUMAN (2-297): 6.2e-78: 242: 42.42
+	Dm
		1213421 AKT1_DROME (1-324): 7.76e-133: 411: 26.06		MSIR6_DROME (3-300): 9.51e-56: 186: 28.25
+	Rn
		1144336 AKT3_RAT (2-335): 9.83e-132: 403: 22.94		PABP1_RAT (5-186): 7.13e-43: 157: 19.57
+	Hs
		453436 MARK2_HUMAN (3-718): 1.11e-145: 450: 18.04		ROA1_HUMAN (85-183): 1.84e-26: 108: 33.33
+	Hs
		516724 KS6B2_HUMAN (6-405): 5.48e-130: 399: 21.79		PABP1_HUMAN (5-186): 8.2e-43: 157: 19.57
+	Hs
		161966 MARK3_HUMAN (3-718): 4.22e-150: 460: 19.13		HNRDL_HUMAN (3-88): 1.69e-15: 78.1: 27.91
+	Hs
		453680 KS6B2_HUMAN (6-405): 5.48e-130: 399: 21.79		ROA1_HUMAN (85-183): 1.84e-26: 108: 33.33
+	Sc
		376578 KAPB_YEAST (3-309): 4.02e-111: 346: 26.75		PABP_YEAST (1-79): 6.35e-16: 79.7: 27.50
+	Hs
		609768 NEK2_HUMAN (6-261): 2.63e-48: 179: 40.91		ROA2_HUMAN (2-297): 6.2e-78: 242: 42.42
+	Hs
		161996 NEK2_HUMAN (6-261): 2.63e-48: 179: 40.91		HNRDL_HUMAN (3-88): 1.69e-15: 78.1: 27.91