HitPredict

Interactor 1: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Interactor 2: GRDN (Q3V6T2)
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)
Gene: CCDC88A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25798074
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0036064 - ciliary basal body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 841 Hs			1 1871
+	Hs
		681881 AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Mm
		1130947 AKT2_MOUSE (1-333): 2.4e-134: 410: 21.83		GRDN_MOUSE (1-1871): 5.17e-145: 497: 94.77
+	Mm
		682109 AKT1_MOUSE (1-330): 1.93e-132: 405: 23.44		GRDN_MOUSE (1-1871): 5.17e-145: 497: 94.77
+	Hs
		724727 NEK4_HUMAN (1-841): 0: 617: 100.00		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		851713 NEK4_HUMAN (1-841): 0: 617: 100.00		DAPLE_HUMAN (862-1846): 6.94e-26: 119: 11.33
+	Hs
		724967 MARK4_HUMAN (3-718): 6.32e-132: 413: 19.05		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		725010 SIK2_HUMAN (1-725): 1.09e-128: 409: 16.65		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		681696 AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		728513 SIK2_HUMAN (1-725): 1.09e-128: 409: 16.65		MYH11_HUMAN (3-722): 1.6e-26: 121: 12.80
+	Hs
		725223 MARK4_HUMAN (3-718): 6.32e-132: 413: 19.05		MYH10_HUMAN (43-620): 1.66e-20: 101: 9.86
+	Hs
		725242 SIK2_HUMAN (1-725): 1.09e-128: 409: 16.65		MYH10_HUMAN (43-620): 1.66e-20: 101: 9.86
+	Hs
		1268126 MRCKB_HUMAN (3-840): 5.02e-132: 433: 16.63		MY18A_HUMAN (599-1309): 1.19e-12: 75.9: 20.46
+	Mm
		93559 TAOK2_MOUSE (2-835): 7.21e-133: 428: 16.43		DESP_MOUSE (272-1150): 4.57e-10: 67.4: 19.30
+	Hs
		1268074 MARK4_HUMAN (3-718): 6.32e-132: 413: 19.05		MY18A_HUMAN (599-1309): 1.19e-12: 75.9: 20.46
+	Hs
		1313528 SIK2_HUMAN (1-725): 1.09e-128: 409: 16.65		CP250_HUMAN (1-682): 8.88e-13: 76.2: 11.44
+	Hs
		1344754 SNRK_HUMAN (6-734): 3.73e-131: 411: 15.35		MYH2_HUMAN (1-392): 9.18e-09: 63.1: 10.69
+	Hs
		522572 SNRK_HUMAN (6-734): 3.73e-131: 411: 15.35		MYH1_HUMAN (1-392): 8.09e-09: 63.1: 10.94
+	Hs
		551616 AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44		DESP_HUMAN (244-1208): 1.11e-09: 66.2: 19.09
+	Hs
		724726 NEK2_HUMAN (6-261): 2.63e-48: 179: 40.91		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		551760 NEK8_HUMAN (3-313): 8.4e-60: 218: 37.14		DESP_HUMAN (244-1208): 1.11e-09: 66.2: 19.09