HitPredict

Interactor 1: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Interactor 2: RPGR1 (Q96KN7)
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)
Gene: RPGRIP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26638075, 27173435
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035253 - ciliary rootlet
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 841 Hs			1 1286
+	Hs
		851541 NEK4_HUMAN (1-841): 0: 617: 100.00		FTM_HUMAN (1-1284): 0: 717: 29.80
+	Hs
		1147642 NEK1_HUMAN (3-269): 5.25e-78: 277: 50.56		FTM_HUMAN (1-1284): 0: 717: 29.80
+	Hs
		724727 NEK4_HUMAN (1-841): 0: 617: 100.00		MYH9_HUMAN (12-620): 4.46e-21: 102: 9.69
+	Hs
		1268126 MRCKB_HUMAN (3-840): 5.02e-132: 433: 16.63		MY18A_HUMAN (160-819): 1.38e-30: 134: 8.98
+	Hs
		1268074 MARK4_HUMAN (3-718): 6.32e-132: 413: 19.05		MY18A_HUMAN (160-819): 1.38e-30: 134: 8.98
+	Hs
		522572 SNRK_HUMAN (6-734): 3.73e-131: 411: 15.35		MYH1_HUMAN (19-663): 2.61e-25: 116: 8.92
+	Hs
		1344754 SNRK_HUMAN (6-734): 3.73e-131: 411: 15.35		MYH2_HUMAN (7-658): 8.45e-25: 114: 10.72
+	Mm
		93559 TAOK2_MOUSE (2-835): 7.21e-133: 428: 16.43		DESP_MOUSE (57-812): 1.11e-16: 88.6: 8.05
+	Hs
		724967 MARK4_HUMAN (3-718): 6.32e-132: 413: 19.05		MYH9_HUMAN (12-620): 4.46e-21: 102: 9.69
+	Hs
		725010 SIK2_HUMAN (1-725): 1.09e-128: 409: 16.65		MYH9_HUMAN (12-620): 4.46e-21: 102: 9.69
+	Hs
		681696 AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44		MYH9_HUMAN (12-620): 4.46e-21: 102: 9.69
+	Hs
		551616 AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44		DESP_HUMAN (57-812): 4.84e-18: 92.9: 8.83
+	Hs
		725223 MARK4_HUMAN (3-718): 6.32e-132: 413: 19.05		MYH10_HUMAN (7-528): 2.02e-14: 81: 10.48
+	Hs
		725242 SIK2_HUMAN (1-725): 1.09e-128: 409: 16.65		MYH10_HUMAN (7-528): 2.02e-14: 81: 10.48
+	Hs
		551760 NEK8_HUMAN (3-313): 8.4e-60: 218: 37.14		DESP_HUMAN (57-812): 4.84e-18: 92.9: 8.83
+	Hs
		724726 NEK2_HUMAN (6-261): 2.63e-48: 179: 40.91		MYH9_HUMAN (12-620): 4.46e-21: 102: 9.69
+	Hs
		1268102 PLK2_HUMAN (6-260): 3.7e-34: 141: 33.98		MY18A_HUMAN (160-819): 1.38e-30: 134: 8.98