HitPredict

Interactor 1: UB2E1 (P51965)
Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1)
Gene: UBE2E1

Interactor 2: ZNRF2 (Q8NHG8)
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
Gene: ZNRF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32265276, 18615712
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 242
+	Hs
		1242075 UB2E2_HUMAN (4-193): 2.5e-84: 249: 81.96		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		851849 UB2E1_HUMAN (19-193): 2.75e-82: 244: 100.00		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1242076 UB2D4_HUMAN (47-192): 2.38e-81: 239: 63.01		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		919790 UB2D2_HUMAN (47-192): 8.03e-81: 238: 64.38		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		849373 UB2D1_HUMAN (47-192): 3.02e-80: 237: 61.64		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1242072 UB2E3_HUMAN (3-193): 1.26e-78: 235: 77.49		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		895849 UB2D3_HUMAN (47-192): 2.56e-79: 234: 63.70		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		896495 UBE2N_HUMAN (45-192): 8.9e-75: 223: 45.95		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1245511 UB2E2_HUMAN (4-193): 2.5e-84: 249: 81.96		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		1245518 UB2D4_HUMAN (47-192): 2.38e-81: 239: 63.01		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		919793 UB2D2_HUMAN (47-192): 8.03e-81: 238: 64.38		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		849375 UB2D1_HUMAN (47-192): 3.02e-80: 237: 61.64		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		1245509 UB2E3_HUMAN (3-193): 1.26e-78: 235: 77.49		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		895853 UB2D3_HUMAN (47-192): 2.56e-79: 234: 63.70		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		1243628 UB2D4_HUMAN (47-192): 2.38e-81: 239: 63.01		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		919791 UB2D2_HUMAN (47-192): 8.03e-81: 238: 64.38		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		849374 UB2D1_HUMAN (47-192): 3.02e-80: 237: 61.64		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		896498 UBE2N_HUMAN (45-192): 8.9e-75: 223: 45.95		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		895850 UB2D3_HUMAN (47-192): 2.56e-79: 234: 63.70		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		896497 UBE2N_HUMAN (45-192): 8.9e-75: 223: 45.95		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86