HitPredict

Interactor 1: ROA3 (P51991)
Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
Gene: HNRNPA3

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1990904 - ribonucleoprotein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 378 Hs			1 551
+	Hs
		162062 HNRDL_HUMAN (20-303): 9.32e-70: 226: 32.30		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1048080 HNRPD_HUMAN (8-299): 1.73e-54: 184: 34.59		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		609888 ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		453387 ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		162035 HNRDL_HUMAN (20-303): 9.32e-70: 226: 32.30		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		161948 HNRDL_HUMAN (20-303): 9.32e-70: 226: 32.30		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516424 ROA3_HUMAN (1-209): 2.02e-60: 201: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516511 HNRPD_HUMAN (8-299): 1.73e-54: 184: 34.59		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		609957 ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		609764 ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		453478 ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Sc
		376993 HRP1_YEAST (22-375): 8.12e-55: 190: 28.09		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		1048276 HNRPD_HUMAN (8-299): 1.73e-54: 184: 34.59		ZMIZ1_HUMAN (159-374): 8.13e-09: 60.7: 17.72
+	Hs
		516663 ROAA_HUMAN (12-208): 7.23e-36: 135: 38.38		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		453331 ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516358 ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Zm
		8143 A0A1D6ELH4_MAIZE (6-345): 1.09e-19: 92.5: 14.37		A0A1D6ELH4_MAIZE (60-456): 7.52e-26: 113: 13.55
+	Hs
		453107 ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Zm
		10866 A0A1D6F8R0_MAIZE (2-375): 1.44e-18: 88.7: 20.05		C0P861_MAIZE (179-411): 1.38e-09: 63: 19.67
+	Hs
		453598 ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69