HitPredict

Interactor 1: RND2 (P52198)
Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2)
Gene: RND2

Interactor 2: PKP4 (Q99569)
Plakophilin-4 (p0071)
Gene: PKP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 227 Hs			1 1192
+	Hs
		901228 RND3_HUMAN (4-227): 3.64e-100: 292: 64.00		PKP4_HUMAN (1-1192): 0: 1148: 100.00
+	Hs
		1269212 RND1_HUMAN (6-227): 1.9e-83: 249: 53.15		PKP4_HUMAN (1-1192): 0: 1148: 100.00
+	Hs
		900835 RHOA_HUMAN (9-193): 2.25e-83: 248: 47.03		PKP4_HUMAN (1-1192): 0: 1148: 100.00
+	Hs
		852689 RND2_HUMAN (1-227): 7.71e-110: 316: 100.00		PKP3_HUMAN (218-1014): 2.04e-152: 478: 26.92
+	Hs
		716896 RND2_HUMAN (1-227): 7.71e-110: 316: 100.00		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Hs
		716936 RND3_HUMAN (4-227): 3.64e-100: 292: 64.00		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Hs
		900842 RHOA_HUMAN (9-193): 2.25e-83: 248: 47.03		PKP2_HUMAN (156-1014): 1.57e-160: 502: 24.78
+	Hs
		542240 RND2_HUMAN (1-227): 7.71e-110: 316: 100.00		PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54
+	Hs
		717248 RND1_HUMAN (6-227): 1.9e-83: 249: 53.15		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Hs
		716935 RHOA_HUMAN (9-193): 2.25e-83: 248: 47.03		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Dm
		816378 RHO1_DROME (5-191): 6.53e-82: 244: 47.59		Q7PLI0_DROME (521-1098): 1.59e-149: 470: 44.46
+	Hs
		542259 RND3_HUMAN (4-227): 3.64e-100: 292: 64.00		PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54
+	Hs
		542395 RND1_HUMAN (6-227): 1.9e-83: 249: 53.15		PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54
+	Hs
		542258 RHOA_HUMAN (9-193): 2.25e-83: 248: 47.03		PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54
+	Hs
		239091 RND2_HUMAN (1-227): 7.71e-110: 316: 100.00		CTND1_HUMAN (26-872): 2.01e-72: 263: 13.69
+	Hs
		239103 RND3_HUMAN (4-227): 3.64e-100: 292: 64.00		CTND1_HUMAN (26-872): 2.01e-72: 263: 13.69
+	Mm
		677654 RHOA_MOUSE (9-193): 1.89e-83: 248: 47.03		CTND1_MOUSE (26-872): 1.01e-76: 275: 13.66
+	Hs
		239186 RND1_HUMAN (6-227): 1.9e-83: 249: 53.15		CTND1_HUMAN (26-872): 2.01e-72: 263: 13.69
+	Hs
		239102 RHOA_HUMAN (9-193): 2.25e-83: 248: 47.03		CTND1_HUMAN (26-872): 2.01e-72: 263: 13.69
+	Hs
		854084 RHOA_HUMAN (9-193): 2.25e-83: 248: 47.03		GDS1_HUMAN (530-972): 4.81e-75: 263: 16.70