HitPredict

Interactor 1: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	34950606
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032481 - positive regulation of type I interferon production
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 529 Hs			1 427
+	Hs
		238677 IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		238672 IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		853590 IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		853410 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		501021 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23