HitPredict

Interactor 1: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Interactor 2: P121A (Q96HA1)
Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)
Gene: POM121

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005789 - endoplasmic reticulum membrane GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding GO:0031965 - nuclear membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 529 Hs			1 1249
+	Hs
		65040 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		P121C_HUMAN (1-1249): 1.9e-77: 282: 93.93
+	Hs
		134948 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		P121A_HUMAN (1-1249): 2.73e-82: 296: 100.00
+	Hs
		131490 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		P121A_HUMAN (1-1249): 2.73e-82: 296: 100.00
+	Hs
		65034 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		P121C_HUMAN (1-1249): 1.9e-77: 282: 93.93
+	Hs
		65033 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		P121C_HUMAN (1-1249): 1.9e-77: 282: 93.93
+	Hs
		238723 IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37		P121A_HUMAN (1-1249): 2.73e-82: 296: 100.00
+	Hs
		853331 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		POZP3_HUMAN (266-371): 3.14e-26: 109: 75.70
+	Hs
		72719 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		B4DET5_HUMAN (79-778): 1.43e-13: 77.5: 11.14
+	Hs
		853433 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		72691 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		B4DET5_HUMAN (79-778): 1.43e-13: 77.5: 11.14
+	Hs
		131388 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		NU214_HUMAN (91-1211): 3.61e-15: 83.5: 12.90
+	Hs
		72690 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		B4DET5_HUMAN (79-778): 1.43e-13: 77.5: 11.14
+	Hs
		134956 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		131499 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Xl
		852372 IMA5_XENLA (4-529): 2.9e-139: 414: 62.36		Q5EWX9_XENLA (663-1249): 5.31e-12: 72.8: 17.09
+	Hs
		853686 IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81