HitPredict

Interactor 1: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Interactor 2: RAP2B (P61225)
Ras-related protein Rap-2b (EC 3.6.5.2)
Gene: RAP2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 183
+	Hs
		486015 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21
+	Hs
		854154 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2C_HUMAN (1-182): 1.79e-102: 294: 86.26
+	Hs
		854088 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87
+	Hs
		854133 GDS1_HUMAN (1-607): 0: 917: 100.00		RAB1B_HUMAN (4-179): 6.08e-75: 224: 33.90
+	Hs
		854082 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP1B_HUMAN (1-183): 8.66e-74: 221: 61.41
+	Hs
		506444 GDS1_HUMAN (1-607): 0: 917: 100.00		RALB_HUMAN (4-164): 2.85e-48: 157: 46.91
+	Hs
		854121 GDS1_HUMAN (1-607): 0: 917: 100.00		DIRA2_HUMAN (3-161): 2.72e-48: 157: 49.38
+	Xl
		292764 GDS1A_XENLA (1-607): 0: 899: 85.50		RALBB_XENLA (4-164): 8.07e-49: 159: 46.91
+	Xl
		292765 GDS1A_XENLA (1-607): 0: 899: 85.50		RALBA_XENLA (4-164): 4.39e-49: 159: 46.91
+	Dm
		51787 GDS1_DROME (62-536): 0: 540: 31.27		O96692_DROME (1-183): 3.91e-77: 229: 67.76
+	Dm
		51795 GDS1_DROME (62-536): 0: 540: 31.27		Q962I2_DROME (4-177): 3.75e-51: 164: 42.62
+	Dm
		51789 GDS1_DROME (62-536): 0: 540: 31.27		RALA_DROME (4-164): 1.9e-50: 162: 45.96