HitPredict

Interactor 1: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	11948427, 20709748, 28514442, 31980649, 33961781, 31871319, 35271311, unassigned2173, 34591642
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 193
+	Hs
		854090 GDS1_HUMAN (1-607): 0: 917: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436217 GDS1_HUMAN (1-607): 0: 917: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		854093 GDS1_HUMAN (1-607): 0: 917: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		854081 GDS1_HUMAN (1-607): 0: 917: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545277 GDS1_HUMAN (1-607): 0: 917: 100.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		854080 GDS1_HUMAN (1-607): 0: 917: 100.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		854087 GDS1_HUMAN (1-607): 0: 917: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94