HitPredict

Interactor 1: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Interactor 2: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	11948427, 20709748, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 184
+	Hs
		854082 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11
+	Hs
		854090 GDS1_HUMAN (1-607): 0: 917: 100.00		RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08
+	Hs
		854133 GDS1_HUMAN (1-607): 0: 917: 100.00		RAB1B_HUMAN (4-179): 2.82e-72: 218: 30.51
+	Hs
		854083 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27
+	Hs
		854154 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2C_HUMAN (1-183): 3.8e-64: 197: 61.75
+	Hs
		486015 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2A_HUMAN (1-181): 3.65e-62: 192: 62.43
+	Hs
		349994 GDS1_HUMAN (1-607): 0: 917: 100.00		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		349206 GDS1_HUMAN (1-607): 0: 917: 100.00		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Dm
		51787 GDS1_DROME (62-536): 0: 540: 31.27		O96692_DROME (1-181): 4.72e-60: 186: 56.91
+	Dm
		51795 GDS1_DROME (62-536): 0: 540: 31.27		Q962I2_DROME (4-184): 1.44e-54: 173: 49.20