HitPredict

Interactor 1: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12200137
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1124 Hs			1 509
+	Mm
		957236 JAK2_MOUSE (4-1101): 0: 897: 48.38		SHC1_MOUSE (105-508): 5.58e-66: 225: 17.12
+	Mm
		403446 JAK2_MOUSE (4-1101): 0: 897: 48.38		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		145961 JAK2_HUMAN (7-1101): 0: 889: 47.80		SH2B2_HUMAN (56-507): 1.2e-64: 223: 13.94
+	Hs
		238363 JAK2_HUMAN (7-1101): 0: 889: 47.80		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		238342 JAK2_HUMAN (7-1101): 0: 889: 47.80		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Mm
		222647 JAK2_MOUSE (4-1101): 0: 897: 48.38		SOCS5_MOUSE (26-489): 7.82e-58: 202: 15.11
+	Mm
		980968 JAK2_MOUSE (4-1101): 0: 897: 48.38		YES_MOUSE (343-488): 6.44e-53: 189: 23.53
+	Hs
		238346 JAK2_HUMAN (7-1101): 0: 889: 47.80		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		238330 JAK2_HUMAN (7-1101): 0: 889: 47.80		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		238395 JAK2_HUMAN (7-1101): 0: 889: 47.80		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		666033 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		209001 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		522840 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		442789 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		557630 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		412070 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		789054 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		789042 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337384 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Mm
		337615 ABL1_MOUSE (760-1102): 2.57e-95: 331: 29.48		ABL1_MOUSE (354-507): 2.92e-35: 142: 24.03