HitPredict

Interactor 1: MP2K6 (P52564)
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
Gene: MAP2K6

Interactor 2: MP2K6 (P52564)
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
Gene: MAP2K6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.812

The method score is based on:

Property Details
Experiments 28205554, 19141286
Identification Methods fluorescent resonance energy transfer, molecular sieving, x ray scattering, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0001649 - osteoblast differentiation
GO:0001934 - positive regulation of protein phosphorylation
GO:0002931 - response to ischemia
GO:0004674 - protein serine/threonine kinase activity
and 30 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 334
Hs

1 334
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Last updated: 15 Jul 2024